Varenicline, more commonly known by the brand names Chantix or Champix, is a smoking cessation aid. Its action is complex; essentially it interferes with the receptors in the brain which make smoking an enjoyable experience. It helps smokers quit in two ways:

• Mildly stimulates nicotine receptors so the urge to smoke is not as strong;
• Prevents nicotine from binding with receptors so there is little enjoyment or satisfaction from smoking.

Studies show that smokers who buy varenicline to help with quitting are about 50 percent more successful than those who try to quit on their own.

Kicking the Habit

As any smoker knows, nicotine is a tough habit to break. Cravings often overwhelm even the most determined willpower. Varenicline reduces the strength of cravings, but the medication alone is unlikely to make a reluctant patient quit -- it still takes determination and effort. Buy varenicline only when ready to make a commitment to kicking the habit.

There a numerous quitting "schedules" utilized with varenicline, though most of them are only slight variations of a 12-week plan:

• Choose a "quit date" and start treatment 7 to 10 days prior.
• Take 0.5 mg once per day for 3 days.
• On day 4, increase to 0.5 mg twice per day until day day 7.
• On day 7, start taking 1 mg twice per day for the next 11 weeks.

The medication should be at full strength between days 7 and 12. By the "quit date" cravings should be considerably reduced, and withdrawal symptoms much more tolerable than without treatment. Most smokers are able to stop, or at least considerably reduce, smoking by days 7 to 10, though some continue for a few weeks longer.

It's not unusual for a quitter to give in occasionally and have a cigarette, especially in the first few weeks of treatment. This is not a big deal; the medication should make the cigarette much less enjoyable than anticipated, and is not a major setback to quitting.

Smokers unable to quit completely after 12 weeks of treatment should consider trying other methods of quitting.

Precautions & Adverse Reactions

Smokers with certain preexisting conditions should not buy varenicline without first talking with a doctor about potential risks:

• Kidney or heart disease
• History of mental disorders
• History of allergic reaction to other medications

Use of this product should generally be avoided if pregnant or breast-feeding.

Most side effects are mild and transient, disappearing entirely after a few days of treatment. The most commonly experienced side effects are only cause for concern if severe or persistent:

• Nausea
• Vomiting
• Heartburn
• Headache
• Constipation
• Appetite changes
• Unpleasant taste in mouth
• Difficulty sleeping
• Vivid or unusual dreams

More serious side effects are rare, but do call for medical attention:

• Pain or burning sensation in legs or feet
• Difficulty moving arms or legs
• Difficulty breathing or talking
• Severe rash on skin
• Blisters in mouth
• Pain in chest, back, arms, neck or jaw
• Excessive sweating

There is some evidence that patients using varenicline may experience depression, including suicidal thoughts or behavior. It is unclear, however, if this is due to the medication or a symptom of nicotine withdrawal.

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